Schedule¶

Daily schedule of classroom sessions.
Complete homework (listed in the Assignments column) before class starts on that day.
The Pages column contains links to materials we will use during class that day and are not part of the homework.

Mondays are marked by bold font.

Date	Topic	Assignments	In-Class Page(s)
Jan 30	Welcome and Introduction	none	Welcome Syllabus Introduction
Jan 1	Movement	Kinematics	Movement
Feb 6	Anatomy	Basic Neuroanatomy	Anatomy
Feb 8	NeuroMuscular Coding	Rate Coding and the Control of Muscle Force (click on either the full text or pdf link to read)	NeuroMuscular Coding
Feb 13	Movement Control: Antagonistic Pairs	Neuronal control of leech behavior: Figure 1, Figure 2, Section 3.2 Local Bending (including section 3.2 Figures);	Movement Control: Antagonistic Pairs
Feb 15	Cells Types and Circuits	The first two sections (“Cell Types” and “Manual Database Exploration”) of the Cell Types Interactive Notebook; On the function of recurrent inhibition in the spinal cord	Cell Types and Circuits
Feb 20	Strength	The brain can make you stronger; Assessment of Neuroplasticity With Strength Training	Strength
Feb 22	Movement Control: Motor Cortex	On the relations between the direction of two-dimensional arm movements and cell discharge in primate motor cortex. Focus on the following sections: Abstract, Introduction, Methods “Data Analysis” first two paragraphs (we will cover equations 1 and 6 in class), Results “Behavioral Data” “Quantitative studies: Relations to the direction of movement” “Relations between the frequency of discharge and direction of movement: Directional tuning curve”, and Discussion; Muscle and Movement Representations in the Primary Motor Cortex; Motor Cortex Connectivity	Movement Control: Motor Cortex
Feb 27	Action Control: CPGs	Central pattern generators and the control of rhythmic movements (stop before “neuromodulators”); Reciprocal Inhibition and Postinhibitory Rebound Produce Reverberation in a Locomotor Pattern Generator	Action Control: CPGs
March 1	Action Control: CPGs	Central pattern generators and the control of rhythmic movements: “Coupling and Coordination” (pages R991-993); How the brainstem controls orofacial behaviors comprised of rhythmic actions	Action Control: CPGs
March 6	Action Control: Brainstem	A functional map for diverse forelimb actions within brainstem circuitry	Action Control: Brainstem
March 6	Editorial DUE 11 PM	Basic Movement Control	Editorials
March 8	Orientation and Action Selection: Tectum	The tectum/superior colliculus as the vertebrate solution for spatial sensory integration and action sections: The tectum/SC’s intrinsic networks and their computations (The tectum/SC’s conserved laminar structure and The lamprey tectum’s sensory and motor maps and circuit mechanisms) , Sensorimotor transformation, premotor outputs, and behavior selection, and Conclusions and future directions; Orienting our view of the superior colliculus: specializations and general functions	Orientation and Action Selection: Tectum
March 11-26	Spring Break
March 27	Dealing with High Dimensional Data	(Get a gist of this material and we will look at them together as well) Geometric View of Data; Dimensionality Reduction	High dimensional data/techniques/thinking
March 29	Action Selection: Leech Swim/Crawl	Optical Imaging of Neuronal Populations During Decision-Making	Action Selection: leech swim/crawl
April 3	Action Selection: Amygdala	Integrated Control of Predatory Hunting by the Central Nucleus of the Amygdala	Action Selection: Amygdala
April 5	Action Control: Motor Cortex	Neural population dynamics during reaching (SKIP “Population-level quantification”); A Dynamical Basis Set for Generating Reaches(SKIP the following sections: “Rotations are a Dominant Motif in the Population Response” (on page 5-6), “Rotational Structure is Absent for Muscles and Traditional Models” (on page 7), “Interpretation of Why “Tuning” Changes With Time (on page 9), “Pitfalls of the Population PSTH” (on page 9-11))	Action Control: Motor Cortex
April 10	Action Control: Motor Cortex	Motor Cortex Embeds Muscle-like Commands in an Untangled Population Response(SKIP the following sections of Results (spanning pg 960-962): “Hypothesis-based predictions of neural responses”, “Alternative Predictions”, “Signals Introduced by optimization yield incidental correlations”)	Action Control: Motor Cortex
April 12	Action Control: Spinal Cord (high D)	Neurons that control walking go round in circles; Movement is governed by rotational neural dynamics in spinal motor networks	Action Control: Spinal Cord (high D)
April 17	Basal Ganglia and Cerebellum Introduction	Liqun Luo (2020) Cerebellum; Liqun Luo (2020) Basal Ganglia	Canonical Circuits
April 19	Action Sequencing: Basal Ganglia	Optogenetic Editing Reveals the Hierarchical Organization of Learned Action Sequences	Action Sequencing: Basal Ganglia
April 24	Action Sequencing: Basal Ganglia	The Striatum Organizes 3D Behavior via Moment-toMoment Action Selection sections: Summary, Intro, Results (introductory paragraph), Pathway decorrelations facilitate behavioral encoding and decoding, Figure 3, Sequence-specific neural representations for syllables, Figure 4, The DLS is required for moment-to-moment action selection, Figure 7, and Discussion	Action Sequencing: Basal Ganglia
April 24	Editorial DUE 11 PM	Basic Action Control	Editorials
April 26	Coordination: Cerebellum	A quantitative framework for whole-body coordination reveals specific deficits in freely walking ataxic mice	Coordination: Cerebellum
May 1	Context: Cerebellum	Learning to expect the unexpected: rapid updating in primate cerebellum during voluntary self-motion	Context: Cerebellum
May 3	Movement Effects on Sensory Systems	How do fish make electricity?; Studying electric fish in the field; Perks and Sawtell 2019 pg 318-326 and 332-334 (sections 11.3-11.4.3 and 11.6.2)	Movement Effects on Sensory Systems
May 8	Movement Effects on Sensory Systems	Perks and Sawtell 2019 pg 327-330 (section 11.5)	Movement Effects on Sensory Systems
May 10	Wrap Up	Assess: Connecting neuronal circuits for movement
May 16	Editorial DUE 11 PM	Beyond Basic Control	Editorials

May 11-15 Reading Period May 16-19 Final Exam Period

Neurobiology of Movement

Schedule

Schedule¶